Iranian Heart Association Iranian Heart Journal 23 1 2022 01 01 Left Atrial Myxoma With Atypical Echocardiographic Features 233 236 142630 EN Azin Alizadehasl Echocardiography and Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Mohammad Javad Alemzadeh-Ansari Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. 0000-0003-4698-3244 Atousa Mostafavi Shariati Hospital, Tehran University of Medical Sciences, Tehran, IR Iran. Sedigheh Saedi Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Hossein Kamranzade Fumani Department of Internal Medicine, School of Medicine Hematology-Oncology and Stem Cell Transplantation Research Center Shariati Hospital Tehran University of Medical Sciences, Tehran, IR Iran. Tahereh Saedi Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. 0000-0002-6335-7168 Journal Article 2020 11 25 Accurate diagnoses of cardiac masses constitute a challenge to the cardiologist. Echocardiography plays an essential role, but differentiating between benign and malignant masses that may mimic the features of each other may not be easy by echocardiography. Myxomas are primary benign tumors of the heart with typical echocardiographic features that are generally found in certain locations in the heart. Nonetheless, they are occasionally found in atypical locations in the heart chambers and echocardiographic features mimicking malignant tumors. Myxomas may present with obstructive, embolic, and constitutional symptoms, or they might be found incidentally based on the tumor size and location. Herein, we describe a 78-year-old man with a cardiac mass with echocardiographic features inconsistent with a benign tumor, although further evaluation confirmed it as a myxoma. Benign or malignant cardiac masses could mimic the typical imaging features of each other, and the diagnosis should be based on pathologic findings. <strong><em>(Iranian Heart Journal 2022; 23(1): 233-236)</em></strong> https://journal.iha.org.ir/article_142630_b0803575035514b2dd95fd52d254e27d.pdf