Iranian Heart Association Iranian Heart Journal 9 2 2008 06 01 Effect of Preoperative Aspirin Use on Postoperative Bleeding and Perioperative Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Surgery 18 22 183367 EN Journal Article 2023 11 19 Background- Continuation or discontinuation of aspirin use in the preoperative period for patients<br />scheduled for elective cardiac surgery has continued to be controversial. In this study, we tried<br />to evaluate clinical outcomes (mortality, postoperative bleeding and perioperative myocardial<br />infarction) in patients who underwent first elective coronary artery bypass grafting and<br />received aspirin during the preoperative period.<br />Methods- The study was a prospective, randomized and single-blinded clinical trial. Two-hundred<br />patients were included in the study and divided into two groups. One group received aspirin<br />80-160 mg and in the other group, aspirin was stopped at least for seven days before operation.<br />The primary end points of the study were in-hospital mortality rate and hemorrhage-related<br />complications (postoperative blood loss in the intensive care unit, reexploration for bleeding<br />and red blood cell and non-red blood cell transfusion requirements). The secondary end point<br />was perioperative myocardial infarction.<br />Results- There were no differences in patients’ characteristics among aspirin users and non-aspirin<br />users. We found a significant difference between postoperative blood loss (608±359.7 ml vs.<br />483±251.5 ml; P=0.005) and red blood cell product requirements (1.32±0.97 units packed<br />cells vs. 0.94±1.02 units packed cells; P=0.008) in the two groups. There was no significant<br />difference between the two groups regarding platelet requirements and the rate of in-hospital<br />mortality and reexploration for bleeding. Similarly, we found no significant difference in the<br />incidence of definite and probable perioperative myocardial infarction (P=0.24 and P=0.56,<br />respectively) and in-hospital mortality between the two groups.<br />Conclusion- Preoperative aspirin administration increased postoperative bleeding and red blood cell<br />requirements with no effect on mortality, reexploration rate and perioperative myocardial<br />infarction (Iranian Heart Journal 2008; 9 (2):18-22). https://journal.iha.org.ir/article_183367_b15c2cbd6c13b0139cc92a414df00e1b.pdf