Iranian Heart Association Iranian Heart Journal 20 1 2019 01 01 Association Between 25-Hydroxyvitamin D Levels and the Carotid Intima-Media Thickness 15 19 82648 EN Maryam Shojaeifard Echocardiography Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Negar Omidi Cardiac Primary Prevention Research Center, Department of Cardiology, School of Medical Sciences, Tehran, IR Iran. Saba Homatash Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Ali Daryanavard Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Anahita Esmaeli Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Hamidreza Rahmanpour Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, IR Iran. Sajad Erami Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran. Hossein Dehghani Mohammad Abadi Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran. Journal Article 2019 02 12 <span>Background: There are insufficient data on the association between the serum level of vitamin D and the carotid intima-media thickness (CIMT). The aim of this study was to investigate the association between the level of serum 25-hydroxyvitamin D and the CIMT. Methods: This cross-sectional study recruited 341 patients. The level of 25-hydroxyvitamin D was measured with radioimmunoassay, and the CIMT was measured with color Doppler ultrasound. Results: The mean serum level of 25-hydroxyvitamin D was 14.88±14.63 ng/mL in the patients with asignificant carotid artery involvement and 17.02±13.56 ng/mL in those without a carotid involvement, with the difference between the 2 groups constituting statistical significance (P=0.034). The prevalence rate of vitamin D deficiency in those with and without a carotid involvement was 88.6% and 74.4%; the rate was significantly higher in the former group (P=0.039). Conclusions: Our study confirmed recent suggestions regarding the association between vitamin D deficiency and the progress of atherosclerosis in carotid arteries as CIMT.</span> https://journal.iha.org.ir/article_82648_be12e7f0f8de169a361afbd150d2ce59.pdf