Iranian Heart Association Iranian Heart Journal 13 1 2012 03 01 SEVERE KNEE DEFORMITY IN A CYANOTIC PATIENT: A CASE REPORT 46 49 83209 EN Sami Samiee Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Zarnaz Zohravi Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Nooshin Shirzad 1-Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Maryam Mohsenikia Javaheri Hospital, Azad University of Medical Sciences, Tehran, Iran Nazilla SeyedForotan Javaheri Hospital, Azad University of Medical Sciences, Tehran, Iran Vahid Haghpanah Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mostafa Qorbani Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Fahime Saboor Javaheri Hospital, Azad University of Medical Sciences, Tehran, Iran Ramin Baghaei Associate Professor in Cardiac Surgery, Rajaie Cardiovascular, Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2019 03 01 Hypertrophic osteoarthropathy is one of the rheumatologic complications in cyanotic heart disease. The severity of involvement depends on the degree and duration of a right-to-left shunt. The mechanism is related to the bypass of mediators from the lung and entrapment in the limbs. These mediators induce local cell proliferation in the bone and soft tissue. Herein, we report a cyanotic patient with severe involvement and deformity in his knee. https://journal.iha.org.ir/article_83209_8ffce3d46f68ca02795dbffec64095f1.pdf