Iranian Heart Association Iranian Heart Journal 13 3 2012 09 01 IS THERE ANY ASSOCIATION BETWEEN CD14 POLYMORPHISM AND CORONARY ARTERY DISEASE? 6 10 83247 EN Behshad Naghshtabrizi Behshad Naghshtabrizi, MD;Assistant Professor of Cardiology,Department of Cardiology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran Mehrdad Hajilooi Mehrdad Hajilooi, MD, PHD;Assistant Professor of Immunology,Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran Azadeh Mozayanimonfared Azadeh Mozayanimonfared, MD;Resident of Cardiology,Department of Cardiology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran Shahram Homayounfar Shahram Homayounfar, MD;Associate Professor of Cardiology, Department of Cardiology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran Raana Shoshtari Raana Shoshtari, MD;Hamedan University of Medical Sciences, Hamedan, Islamic Republic of Iran Journal Article 2019 03 02 Background: Several pro-inflammatory single nucleotide polymorphisms have been associated with the development of atherosclerosis and coronary artery disease (CAD). CD₁₄+ monocytes are one of these molecules due to their ability to produce variable cytokines. Association between CD₁₄+monocytes and carotid intimal-medial thickness has been previously identified. In this study, we tried to evaluate the relation between CD₁₄ polymorphism and CAD.<br />Methods: We evaluated 200 patients divided into two matched groups based on the result of their coronary angiography: 100 patients who had significant lesion (s) in their coronary arteries were allocated to the case group, and the other 100 without CAD were categorized as the control group. The polymorphism of CD₁₄ was determined via allele-specific polymerase chain reaction (PCR).<br />Results: The frequency of the genotypes (CC, TT, and CT) was 45%, 7%, and 48% in the case group and 24%, 38%, and 38% in the control group: there was a significant difference in the allele genotype frequency between the two groups (pvalue<0/001).<br />Conclusion: CD₁₄ polymorphism was associated with CAD https://journal.iha.org.ir/article_83247_4997b1eb758112ab9c772813e2abc604.pdf