Iranian Heart Association Iranian Heart Journal 3.4 2.3 2002 09 01 INCIDENTAL MESOTHELIAL/MONOCYTIC CARDIAC EXCRESCENCE AND LITERATURE REVIEW 61 65 83523 EN MAJID MALEKI SHAHEED RAJAIE CARDIOVASCULAR MEDICAL CENTER, MELLAT PARK, VALI ASR AVENUE, TEHRAN, IRAN A SAFAEI F ROUSHANALI M MOSHKANI FARAHANI Journal Article 2019 03 04 We present a case of the so-called mesothelial monocytic incidental cardiac excrescences (MICE) of the heart and a brief review of related literature.<br />The patient was a 74- year- old woman. She had no history of previous cardiac instrumentation and underwent pericardial drainage and biopsy due to cardiac tamponade. A tissue sample was submitted as thrombus attached to the pericardium. Histologically, these lesions were composed of a mixture of plump histiocytoid cells, a papillary and strip arrangement of cuboidal cells, and various sized vacuoles and fibrin. The nests of cuboidal cells resembled cancer cells but showed features of mesothelial cells. Immunohistochemically, histiocytic cells were positive for CD68 but negative for cytokeratin. The cuboidal cells were positive for cytokeratin but negative for CD 68. These lesions were probably reactive because of their heterogeneous components. The significance of MICE is its possibility of being misdiagnosed as metastatic carcinoma. https://journal.iha.org.ir/article_83523_046a1132e37c3405512b13be444c14d5.pdf