Iranian Heart Journal

Iranian Heart Journal

Effects of Dexmedetomidine on Endogenous Antioxidant Levels and Clinical Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial

Document Type : Original Article

Authors
Naser Kachoueian 1
Ziae Totonchi 2
Maede Barari 3
Azadeh Fazli 4
Maryam Pazhoha 4
Yaser Toloueitabar 2
Amirnaser Jadbabaie 2
Koroush Tirgarfakheri 2
Simin Shams 2
Meysam Mortazian 5
1 Department of Cardiac Surgery, Imam Hossein Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
3 Pharmacology and Toxicology Department, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, IR Iran.
4 Mazandaran University of Medical Sciences, Tehran, IR Iran.
5 AJA University of Medical Sciences Tehran IR Iran.
Abstract
Background: Dexmedetomidine reduces perioperative catecholamine concentrations and confers hemodynamic and sympathetic stability. It adjusts coronary blood flow and is known as one of the ideal anesthetic drugs, especially for patients undergoing coronary artery bypass graft surgery (CABG). The present study was performed to evaluate the potential of dexmedetomidine to protect against oxidative stress during CABG.
 
Methods: The present double-blinded randomized clinical trial was performed on 58 patients undergoing CABG at Rajaie Cardiovascular Medical and Research Center. After anesthesia induction, the patients were allocated to the trial (dexmedetomidine) and control (normal saline solution) groups. Total antioxidant capacity and malondialdehyde were measured in samples obtained from arterial catheters before the intervention, after pump weaning, and 24 hours after intensive care unit (ICU) admission.
 
Results: Only total antioxidant capacity and malondialdehyde at the third measurement point at the ICU were lower in the trial group than in the control group. The levels of circulatory antioxidants were higher in the trial group than in the control group before the intervention and after pump weaning. No significant differences were observed regarding circulatory antioxidant levels between the trial and control groups.
 
Conclusions: Dexmedetomidine infusion before and during CABG might improve endocardial blood flow and hemodynamic stability among patients undergoing CABG. (Iranian Heart Journal 2023; 24(3): 24-31)
Keywords
Oxidative stress
CABG
Dexmedetomidine
Cardiopulmonary bypass
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Iranian Heart Journal
Volume 24, Issue 3
Summer 2023
Pages 24-31