Iranian Heart Journal

Iranian Heart Journal

Impact of Vitamin E Supplementation on Inflammatory and Nutritional Markers in Patients Undergoing Hemodialysis With Chronic Kidney Disease: A Randomized Controlled Trial

Document Type : Original Article

Authors
Farzaneh Banazadehtaheri 1
Hananeh Baradaran 2
Farahnaz Pasha 3
Maryam Shiehmorteza 4
Alireza Banazadehtaheri 5
Sajjad Sadeqi 5
1 Department of Pharmacology, Faculty of Pharmacy, Islamic Azad University, Tehran Medical Branch, Tehran, IR Iran.
2 Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran.
3 Department of Nephrology, Faculty of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, IR Iran.
4 Department of Clinical Pharmacy, Faculty of pharmacy, Islamic Azad University, Tehran Medical Branch, Tehran, IR Iran.
5 Department of Nursing and Midwifery, Islamic Azad University, Semnan, IR Iran.
Abstract
Background: Chronic kidney disease (CKD) is a worldwide concern, and individuals undergoing hemodialysis (HD) are at high risk for cardiovascular disease because of malnutrition and chronic inflammation. This study evaluated the efficacy of vitamin E (VitE) supplementation in modulating nutritional and inflammatory markers in participants undergoing HD.

Methods: This double-blind, randomized, controlled trial lasted 12 weeks and included 40 participants undergoing HD who received 400 IU of VitE daily or placebo. Inflammatory markers (ferritin, C-reactive protein [CRP], and erythrocyte sedimentation rate [ESR]) and nutritional markers (body mass index [BMI] and serum albumin) were assessed at baseline and after the intervention. Lipid profile and HD adequacy were also evaluated.

Results: Participants receiving VitE exhibited significant improvements in nutritional markers (serum albumin and BMI) and inflammatory markers (ferritin, CRP, and ESR) compared with the placebo group. Nonetheless, lipid profile and HD adequacy did not significantly improve in either group.

Conclusions: VitE supplementation improved nutritional status and reduced inflammation in participants with CKD undergoing HD. Still, additional studies are required to determine long-term efficacy and generalizability. (Iranian Heart Journal 2026; 27(3): 27-36)
Keywords
chronic kidney disease
hemodialysis
vitamin E
inflammation
nutritional status
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Iranian Heart Journal
Volume 27, Issue 3
Summer 2026
Pages 27-36