1
Samsun Educatıon And Research Hospital, Department of Cardiology, Samsun, Turkey.
2
Ordu University Faculty of Medicine, Department of Cardiology, Ordu, Turkey.
Abstract
Aim:This study aimed to evaluate changes in health care utilization associated with sacubitril/valsartan (S/V) treatment by comparing outpatient clinic visits, emergency unit admissions, and hospitalizations before and after S/V treatment. Methods:This retrospective study included 108 patients with heart failure with reduced ejection fraction (HFrEF) (mean [SD] age, 67 [20] years; 83% male; 70% ischemic etiology) who had been using S/V for at least 1 year and were followed at a tertiary hospital between December 2021 and January 2023. Patient data for outpatient visits, emergency unit admissions, and hospitalizations were retrieved from the e-Nabız application. Paired statistical analyses (paired-samples t test, Wilcoxon signed-rank test, and McNemar test) were performed to compare parameters before and after S/V initiation. Results:Significant reductions were observed in the mean annual numbers of outpatient clinic visits (5.10 [1.95] vs 3.05 [1.25]; P < .001) and emergency unit admissions (4.40 [1.10] vs 2.80 [0.85]; P < .001) after S/V initiation. Furthermore, there was a significant decrease in the mean annual number of hospitalizations (3.20 [0.90] vs 1.80 [0.60]; P < .001), length of each stay (6.9 [3.5] vs 3.6 [1.9] days; P < .001), intensive care unit (ICU) admission rate (41% vs 17%; P < .001), and ICU length of stay (3.1 [0.9] vs 1.7 [0.8] days; P < .001). Conclusions:S/V initiation was associated with significant reductions in outpatient clinic visits, emergency unit admissions, and hospitalizations, observed together with clinical and functional improvements in real-life patients with advanced HFrEF. These findings may assist cardiologists in countries where S/V is not reimbursed in deciding on its use. (Iranian Heart Journal 2026; 27(4): 25-39)
Şeker, O. O., Bahadır, N. & Dereli, S. (2026). Association Between Sacubitril/Valsartan and Health Care Use: A Single-Center Retrospective Study From Turkey. Iranian Heart Journal, 27(4), 25-39.
MLA
Şeker, O. O., Bahadır, N., & Dereli, S. "Association Between Sacubitril/Valsartan and Health Care Use: A Single-Center Retrospective Study From Turkey", Iranian Heart Journal, 27, 4, 2026, 25-39.
HARVARD
Şeker O. O., Bahadır N., Dereli S. (2026). 'Association Between Sacubitril/Valsartan and Health Care Use: A Single-Center Retrospective Study From Turkey', Iranian Heart Journal, 27(4), pp. 25-39.
CHICAGO
O. O. Şeker, N. Bahadır & S. Dereli, "Association Between Sacubitril/Valsartan and Health Care Use: A Single-Center Retrospective Study From Turkey," Iranian Heart Journal, 27 4 (2026): 25-39,
VANCOUVER
Şeker O. O., Bahadır N., Dereli S. Association Between Sacubitril/Valsartan and Health Care Use: A Single-Center Retrospective Study From Turkey. Iranian Heart Journal. 2026;27(4):25-39.
