Iranian Heart Journal

Iranian Heart Journal

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in A Young Female: A Case Report

Document Type : Case Report

Authors
Nastaran Kordjazy 1 ΒΆ
Roya Parkhideh 2
Azadeh Sadatnaseri 3
Morteza Foroumandi 4
Piroozeh Taheri 5
1 Department of Anesthesiology and Critical Care, School of Medicine, Golestan University of Medical Sciences, Gorgan, IR Iran.
2 Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IR Iran.
3 Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, IR Iran.
4 Department of Critical Care Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IR Iran.
5 Cardiovascular Research Center, Rajaei Cardiovascular Institute, Tehran, Iran.
Abstract
Cardiac angiosarcoma is a rare and highly aggressive malignancy with nonspecific clinical manifestations, often leading to delayed diagnosis. In this article, we report a 38-year-old woman who presented with diarrhea, dry cough, and a history of blunt chest trauma 3 weeks prior to admission. Initial echocardiography revealed massive pericardial effusion complicated by cardiac tamponade. Further diagnostic evaluation, including cardiac computed tomographic angiography, demonstrated right atrial wall rupture. Intraoperative sampling of the pulmonary nodules and the ruptured atrial wall was performed, and histopathologic examination confirmed metastatic cardiac angiosarcoma. Despite surgical intervention, and given the advanced stage of the tumor, the oncology team recommended palliative care. The patient developed progressive right-sided heart failure and died after a 53-day stay in the intensive care unit. This case highlights the diagnostic challenges of cardiac angiosarcoma and underscores the importance of early recognition and stage-appropriate management to improve clinical outcomes. (Iranian Heart Journal 2026; 27(4): 80-86)
Keywords
angiosarcoma
malignant cardiac tumor
right atrial mass
pulmonary metastasis
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Iranian Heart Journal
Volume 27, Issue 4
Autumn 2026
Pages 80-86